SYNERGISTIC EFFECT OF SUBTOXIC-DOSE CISPLATIN AND TRAIL TO MEDIATE APOPTOSIS BY DOWN-REGULATING DECOY RECEPTOR 2 AND UP-REGULATING CASPASE-8, CASPASE-9 AND BAX EXPRESSION ON NCI-H460 AND A549 CELLS

Objective(s): Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively induce apoptosis in tumor cells, more than half of tumors including non-small cell lung cancer (NSCLC) exhibit TRAIL-resistance.The purpose of this study was to determine whether subtoxic-dose cisplatin and TRAIL could synergistically enhance apop

Australian trans youth seeking medical treatment for gender dysphoria can encounter significant legal barriers to healthcare.Legal requirements for obtaining valid consent to gender-affirming care, first established in 2004, mean that an application to the Family Court is required in many cases before treatment can be provided.The development of Au

Summary: Individuals with coronavirus disease 2019 (COVID-19) frequently develop neurological symptoms, but the biological underpinnings of these phenomena are unknown.Through single-cell RNA sequencing (scRNA-seq) and cytokine analyses of cerebrospinal fluid (CSF) and transpharm online shopping blood from individuals with COVID-19 with neurologica